Running Head: Mendelian Randomization Using Genetic Information to Infer Causality in Observational Data: Mendelian Randomization
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Emerging Themes in Epidemiology Analytic perspective Can we apply the Mendelian randomization methodology without considering epigenetic effects?
Introduction: Instrumental variable (IV) methods have been used in econometrics for several decades now, but have only recently been introduced into the epidemiologic research frameworks. Similarly, Mendelian randomization studies, which use the IV methodology for analysis and inference in epidemiology, were introduced into the epidemiologist's toolbox only in the last decade. Analysis: Mendeli...
متن کاملCan we apply the Mendelian randomization methodology without considering epigenetic effects?
INTRODUCTION Instrumental variable (IV) methods have been used in econometrics for several decades now, but have only recently been introduced into the epidemiologic research frameworks. Similarly, Mendelian randomization studies, which use the IV methodology for analysis and inference in epidemiology, were introduced into the epidemiologist's toolbox only in the last decade. ANALYSIS Mendeli...
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What is Mendelian Randomization? The field of epidemiology has struggled to make headway in determining whether exposures are causal factors for complex diseases, largely because of the problems of confounding, reverse causation, and bias. To overcome the problems inherent in observational studies, epidemiologists have proposed using genetic variants as proxies for exposures.1,2 The idea is to ...
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Associations between modifiable exposures and disease seen in observational epidemiology are sometimes confounded and thus misleading, despite our best efforts to improve the design and analysis of studies. Mendelian randomization-the random assortment of genes from parents to offspring that occurs during gamete formation and conception-provides one method for assessing the causal nature of som...
متن کاملPower and sample size calculations for Mendelian randomization studies using one genetic instrument.
Mendelian randomization, which is instrumental variable analysis using genetic variants as instruments, is an increasingly popular method of making causal inferences from observational studies. In order to design efficient Mendelian randomization studies, it is essential to calculate the sample sizes required. We present formulas for calculating the power of a Mendelian randomization study usin...
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تاریخ انتشار 2017